Is zopiclone a strong sleeping pill?

zopiclone 10mg 10 pills

Zopiclone is a non-benzodiazepine hypnotic agent primarily use to treat insomnia. It is a member of the cyclopyrrolone class of drugs and is available in various dosages, with zopiclone 10 mg and zopiclone 7.5 mg being the most common. These dosages are typically prescribe based on the severity of the patient’s insomnia and their response to the medication.

What is Zopiclone?

Zopiclone works by enhancing the activity of gamma-aminobutyric acid (GABA) in the brain, a neurotransmitter that promotes relaxation and induces sleep. Unlike benzodiazepines, which also affect GABA receptors, zopiclone has a different chemical structure, which leads to its classification as a non-benzodiazepine. Despite this difference, its effects are somewhat similar to those of benzodiazepines, making it effective for short-term treatment of insomnia.

Zopiclone 7.5 mg

Zopiclone 7.5 mg is often consider the standard dosage for adults experiencing difficulty falling asleep or staying asleep. This dosage is generally effective for the majority of patients and is associate with fewer side effects compared to higher doses. The 7.5 mg dose helps individuals fall asleep faster, stay asleep longer, and experience a better quality of sleep. It is particularly useful for those with transient or short-term insomnia, where the need for sleep aid is not chronic but occasional.

Zopiclone 10 mg

Zopiclone 10 mg is typically reserve for patients who do not respond adequately to the 7.5 mg dose. This higher dosage provides a stronger sedative effect, making it suitable for individuals with more severe insomnia or those who have developed a tolerance to lower doses. However, with the increase potency comes a higher risk of side effects, including next-day drowsiness, dizziness, and the potential for dependence and withdrawal symptoms. Therefore, the 10 mg dose should be used with caution and under strict medical supervision.

Efficacy and Onset of Action

Both zopiclone 7.5 mg and zopiclone 10 mg are known for their rapid onset of action, typically inducing sleep within 30 minutes of ingestion. This makes them particularly effective for patients who have difficulty falling asleep. The duration of action for zopiclone generally lasts about 6-8 hours, covering a typical sleep cycle. Patients often report improve sleep quality and fewer awakenings during the night when using these dosages.

Side Effects

Common side effects of zopiclone include:

Bitter taste: Many users report a metallic or bitter taste in their mouth after taking zopiclone.

Dry mouth: This can be uncomfortable but is generally mild.

Drowsiness: This can persist into the next day, especially with the 10 mg dose, affecting daytime alertness.

Dizziness and headache: These are common with many sleep medications and are usually transient.

More serious side effects include:

Amnesia: Short-term memory loss can occur, particularly if the person does not get a full night’s sleep.

Dependence: There is a risk of psychological and physical dependence, especially with prolonge use or higher doses.

Withdrawal symptoms: Symptoms such as anxiety, agitation, and rebound insomnia can occur if the medication is abruptly discontinue.

Use in Special Populations

Elderly patients: Elderly patients are often more sensitive to the effects of sedative-hypnotics, including zopiclone. To reduce the danger of severe sedation and falls, a lower initial dose of 3.75 mg is recommended.

Pregnant and breastfeeding women: Zopiclone is generally not recommende during pregnancy and breastfeeding due to potential risks to the fetus or infant. Alternative treatments should be considere.

Patients with liver or kidney impairment: Dose adjustments may be necessary for individuals with hepatic or renal impairment to avoid accumulation of the drug and increase side effects.

Risks and Precautions

Patients taking zopiclone should be aware of the following precautions:

Avoid alcohol: Combining zopiclone with alcohol can enhance its sedative effects and increase the risk of adverse reactions.

Driving and operating machinery: Due to the potential for next-day drowsiness and impaire coordination, patients should avoid activities that require full alertness until they know how zopiclone affects them.

Potential for abuse: As with all hypnotic medications, there is a potential for misuse and abuse, particularly in individuals with a history of substance abuse.

Comparison with Other Sleep Aids

Compared to other non-benzodiazepine sleep aids, such as zolpidem (Ambien) and eszopiclone (Lunesta), zopiclone is similarly effective but may differ in side effect profiles and duration of action. For example, zolpidem is frequently recommend for short-term use because of its shorter half-life, which lowers next-day sleepiness. Eszopiclone, a stereoisomer of zopiclone, is intended for long-term use and may have a somewhat better side effect profile. Individual responses to these medications, however, can vary, thus the choice of sleep aid should be base on the patient’s specific needs and medical history.


Zopiclone, which comes in 7.5 mg and 10 mg doses, is a powerful and effective drug for the short-term treatment of insomnia.
The 7.5 mg dose is typically sufficient for most patients, providing a balance between efficacy and side effects. The 10 mg dose may be require for patients with severe insomnia, although it has a higher risk of side effects and dependence. As with any drug, it is critical to use zopiclone under the supervision of a healthcare provider, follow the specified dosage, and investigate non-pharmacological ways to insomnia management. Through careful use, zopiclone can significantly improve sleep quality and overall well-being for individuals struggling with sleep disturbances.